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16:0-5 Doxyl PC

产品编号:4095627
规格:1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine, powder
CAS NO:188004-24-2
包装规格:1 MG
产品类别:进口试剂
品牌:Avanti
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40956271 MG7080
产品别名

188004-24-2

16:0-5 Doxyl PC

基本信息
Empirical Formula【经验(实验)分子式】
C46H90N2O10P
Molecular weight
862.19
NACRES
NA.25
General description【一般描述】
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. The excretory and secretory products of helminths has a small hapten-like portion called phosphorylcholine (PC). The 5th carbon of the sn-2 stearic acid chain of 1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine analog has a Doxyl PC, a spin probe attached to it covalently.
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Application【应用】
16:0-5 Doxyl PC may be used:
  • as a component in virus-like large unilamellar vesicles (VL LUVs) to quench 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) fluorescence emission
  • in the preparation of multi-lamellar vesicles (MLVs) as a site-specific quencher to perform fluorescence quenching studies
  • in the preparation of spin-labelled multi-lamellar vesicles (MLVs)

Biochem/physiol Actions【生化/生理作用】
Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.
Preparation Note【制备说明】
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.
产品性质
Assay【测定】
>99% (TLC)
form【形式】
powder
manufacturer/tradename
Avanti Polar Lipids 810601P
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
packaging【包装】
5 mL Clear Glass Sealed Ampule (810601P-1mg)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
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