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16:0-12 Doxyl PC

产品编号:4095618
规格:1-palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine, powder
CAS NO:217499-54-2
包装规格:1 MG
产品类别:进口试剂
品牌:Avanti
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40956181 MG7010
产品别名

217499-54-2

16:0-12 Doxyl PC

基本信息
Empirical Formula【经验(实验)分子式】
C46H90N2O10P
Molecular weight
862.19
NACRES
NA.25
General description【一般描述】
Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes. It is also an important component of the mucosal layer of the colon. 1-palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine (12-NO-PC) is a nitroxide-labeled phospholipid.
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Application【应用】
16:0-12 Doxyl PC is suitable for use:
  • as a lipophilic collisional quencher to prepare liposomes used in lipophilic quenching experiments
  • to prepare liposomes used in nitroxide quenching experiments to examine the location of each NBD (7-nitrobenz-2-oxa-1,3-diazole) probe in mutants
  • as a component in POPC or 1:1 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-1-glycerol (POPG) mixtures to prepare unlabelled large unilamellar liposomes

Biochem/physiol Actions【生化/生理作用】
Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance. It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.
Preparation Note【制备说明】
To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM. href="https://pubs.acs.org/doi/suppl/10.1021/ja804929m/suppl_file/ja804929m_si_001.pdf"target="_blank">Supplemental information
产品性质
Assay【测定】
>99% (TLC)
form【形式】
powder
manufacturer/tradename
Avanti Polar Lipids 810600P
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
packaging【包装】
5 mL Clear Glass Sealed Ampule (810600P-1mg)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
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