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Monoclonal Anti-p53-Biotin 小鼠抗

Monoclonal Anti-p53-Biotin antibody produced in mouse
产品编号:4095530
规格:~1 mg/mL, clone DO-1, ascites fluid, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4095530200 μL9280
产品别名

Monoclonal Anti-p53-Biotin 小鼠抗

Monoclonal Anti-p53-Biotin antibody produced in mouse

基本信息
MDL number
MFCD01864735
NACRES
NA.41
General description【一般描述】
p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
Immunogen【免疫原】
recombinant human wild type p53. The epitope resides beween amino acids 20-25 of human p53.
Application【应用】
Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.
Biochem/physiol Actions【生化/生理作用】
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Other Notes【其他说明】
In order to obtain the best results using various techniques and preparations, we recommend determining optimal working dilutions by titration.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
biotin conjugate
antibody form【抗体形式】
ascites fluid
antibody product type
primary antibodies
clone【克隆】
DO-1, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~53 kDa
species reactivity
human
concentration【浓度】
~1 mg/mL
technique(s)
flow cytometry: suitable
immunocytochemistry: 5-10 μg/mL using human A431
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.5-1 μg/mL using human A431 cell extracts
isotype【同位素/亚型】
IgG2a
UniProt accession no.【UniProt登记号】
P04637
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... TP53(7157)
产品说明
Storage and Stability【储存及稳定性】
For continuous use, store at 2-8℃ for up to one month.
For extended storage, freeze in working aliquots.
Repeated freezing and thawing, or storage in “frostfree”freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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