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Adenosine 3',5'-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt-CAS 93882-12-3-Calbiochem
| 产品编号： | 4095187 |
| 规格： | Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. |
| CAS NO： | 93882-12-3 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4095187 | 10 MG | 992 |
产品别名
93882-12-3
Adenosine 3',5'-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt-CAS 93882-12-3-Calbiochem
Adenosine 3',5'-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H14ClN5O6PS · Na |
| Molecular weight | 493.79 |
| MDL number | MFCD00057683 |
| General description【一般描述】 | Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM). Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Induces the guanine-nucleotide-exchange factor activity of EGFI, also known as Epac (exchange protein directly activated by cAMP), and EGFII towards Rap1 both in vivo and in vitro. Also acts as a potent inhibitor of cGMP specific phosphodiesterase (IC50 = 900 nM). Also inhibits cAMP-specific phosphodiesterases at much higher concentrations (IC50 = 25 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 900 nM against cGMP-specific phosphodiesterase Product does not compete with ATP. Reversible: no Primary Target Protein kinase A and protein kinase G |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C |
| Other Notes【其他说明】 | de Rooij, J., et al. 1998. Nature.396, 474. Kawasaki, H., et al. 1998. Science.282, 2275. Moed, P.J., et al. 1993. Comp. Biochem. Physiol.105A, 711. Connolly, B.J., et al. 1992. Biochem. Pharmacol.44, 2303. Phillips, M.E., and Taylor, A. 1992. J. Physiol.456, 591. Shipston, M.J., and Antoni, F.A. 1992. Endocrinology130, 2213. Datta, R., et al. 1991. Blood78, 83. Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA88, 9219. Sandberg, M., et al. 1991. Biochem. J.279, 521. Unterman, T.G., et al. 1991. Endocrinology128, 2693. Xu, H., et al. 1989. Brain Res.504, 36. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | water: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 10 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
