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Matrix Metalloproteinase-12, Catalytic Domain 人
Matrix Metalloproteinase-12, Catalytic Domain human
| 产品编号： | 4094812 |
| 规格： | recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Matrix Metalloproteinase-12, Catalytic Domain 人
Matrix Metalloproteinase-12, Catalytic Domain human
Macrophage elastase
MMP-12
基本信息
| MDL number | MFCD02688053 |
| NACRES | NA.32 |
| General description【一般描述】 | Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11. |
| Biochem/physiol Actions【生化/生理作用】 | Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin. MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling. |
| Unit Definition【单位定义】 | One unit equals 100 pmol/min at 37 ℃ using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate. |
| Physical form【外形】 | Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5. |
| Legal Information【法律信息】 | Brij is a registered trademark of Croda International PLC |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | calculated mol wt 20.3 kDa |
| UniProt accession no.【UniProt登记号】 | P39900 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... MMP12(4321) |
安全信息
| Hazard Statements | H412 |
| Precautionary Statements | P273 - P501 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 3 |
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Gloves, multi-purpose combination respirator cartridge (US) |
