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Hemopexin from human plasma
产品别名
9013-71-2
Hemopexin from human plasma
Hpxn
HX
HPX
Beta-1B-glycoprotein
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human plasma |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| mol wt【分子量】 | ~57 kDa |
| technique(s) | microbiological culture: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000604 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HPX(3263) |
| packaging【包装】 | 500 μg in poly bottle |
基本信息
| General description【一般描述】 | Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein. |
| Application【应用】 | Hemopexin from human plasma has been used S. aureus surface colonization assay. It has also been used to stimulate mixed lymphocyte cells to determine the biomarkers in acute rejection. |
| Biochem/physiol Actions【生化/生理作用】 | Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol. Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages. |
| Physical form【外形】 | Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
