Carboxy-PTIO, Sodium Salt-Calbiochem

C₁₄H₁₆N₂O₄ · Na

299.28

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Nitric oxide scavenging action

Toxicity: Standard Handling (A)

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (TLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

dark blue

HEPES Buffer: 0.4 mg/mL

ambient

−20℃

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1