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Anti-Calcineurin Aβ Antibody
| 产品编号： | 4088594 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Calcineurin Aβ Antibody
NFAT transcription complex cytosolic component, nuclear factor of activated T-cells, cytoplasmic,
calcineurin-dependent 1, nuclear factor of activated T-cells, cytosolic component 1
基本信息
| eCl@ss | 32160702 |
| General description【一般描述】 | Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal transduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling. The Aα form of calcineurin is a major catalytic subunit gene isoform of calcineurin in most tissues that allows differentiation of Aα from the Aβ and Aγ isoforms. |
| Specificity【特异性】 | Recognizes the Aβ (polyproline) form of calcineurin, a less abundant gene isoform of calcineurin in most tissues. Allows differentiation of Aβ from the A α and A-γ isoforms. Reacts with calcineurin of all mammalian species. |
| Immunogen【免疫原】 | KLH-conjugagted synthetic peptide corresponding to Calcineurin Aβ. |
| Application【应用】 | Research Sub Category GPCR, cAMP/cGMP & Calcium Signaling Research Category Signaling Detect Calcineurin Aβ using this Anti-Calcineurin Aβ Antibody validated for use in WB, IH. |
| Quality【质量】 | Evaluated by Western Blot in human brain lysate. Western Blot Analysis: A 1:1,000 dilution of this antibody detected Calcineurin Aβ on 10 µg of human brain lysate. |
| Linkage【联系】 | Replaces: AB1697 |
| Physical form【外形】 | Affinity purified Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative. |
| Analysis Note【分析说明】 | Control Human brain lysate |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mammals (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000935.1 |
| UniProt accession no.【UniProt登记号】 | O95644 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | Approx. 58 kDa |
| Storage and Stability【储存及稳定性】 | Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will remain unfrozen. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
