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Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor® 488 conjugate

产品编号:4088306
规格:from rabbit, ALEXA FLUOR® 647
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088306100 μL5850
产品别名

Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor® 488 conjugate

Cyclic AMP-responsive element-binding protein 1 (pSer133), cAMP-responsive element-binding protein 1 (pSer133), CREB-1 (pSer133), CREB-A (pSer133), htCREB (pSer133), CREB-B (pSer119)

基本信息
eCl@ss
32160702
NACRES
NA.45
General description【一般描述】
Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.
Specificity【特异性】
Recognizes phosphorylated CREB-A (pSer133), htCREB (pSer133), and CREB-B (pSer119) spliced isoforms reported by (UniProt P16220). May also recognize phosphorylated CREM and ATF-1 that contain homologous sequence to that of the immungen peptide.
Immunogen【免疫原】
KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A.
Epitope: pSer133.
Application【应用】
Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor® 488 conjugate is an antibody against phospho-CREB for use in Immunofluorescence.
Research Sub Category
Transcription Factors
The unconjugated antibody (Cat. No. 06-519) is shown to be suitable also for Electrophoretic Mobility Shift Assay (EMSA), immunohistochemistry, and Western blotting applications.
Research Category
Epigenetics & Nuclear Function
Quality【质量】
Evaluated by Immunofluorescence in rat brain tissue.

Immunofluorescence Analysis: A 1:50 dilution of this antibody detected phospho-CREB (Ser133) in rat brain tissue.
Physical form【外形】
Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Affinity purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
Legal Information【法律信息】
ALEXA FLUOR is a registered trademark of Life Technologies
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
ALEXA FLUOR® 647
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
human, mouse, rat
species reactivity (predicted by homology)
Xenopus (based on 100% sequence homology), canine (based on 100% sequence homology), guinea pig (based on 100% sequence homology), chicken (based on 100% sequence homology), porcine (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)
immunofluorescence: suitable
isotype【同位素/亚型】
IgG1
NCBI accession no.【NCBI登记号】
NP_604391
UniProt accession no.【UniProt登记号】
P16220
shipped in【运输】
wet ice
Gene Information
human ... CREB1(1385)
产品说明
Target description【目标描述】
~43 kDa observed.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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