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Anti-LAP2 Antibody
产品编号: | 4088214 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-LAP2 Antibody
LEM domain containing 4, TP alpha, TP beta/gamma, TPRP isoform alpha, TPRP isoforms beta/gamma, Thymopoietin isoform alpha, Thymopoietin, isoforms beta/gamma, Thymopoietin-related peptide isoform alpha, Thymopoietin-related peptide isoforms beta/gamma, l
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups: the constitutively expressed lamin B and the developmentaly regulated lamin A. The best characterized isoforms of lamin binding protein LAP2 are LAP2α and LAP2β. LAP2β is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2α has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization. |
Specificity【特异性】 | Predicted to cross-react with canine (dog) and rat based on sequence homology. This antibody recognizes LAP2. |
Immunogen【免疫原】 | KLH-conjugated synthetic linear peptide corresponding to LAP2. |
Application【应用】 | Research Sub Category Cytoskeletal Signaling Anti-LAP2 Antibody is an antibody against LAP2 for use in WB, IC & IF. Immunofluorescence: Representative lot data. This antibody was used to detect the nuclear lamina by immunofluorescence. Immunocytochemistry: Representative lot data. A previous lot was used in confocal fluorescent analysis of A431, HeLa and NIH/3T3 cells using anti-LAP2 rabbit polyclonal antibody (Red). Actin filaments have been labeled with AlexaFluor Research Category Epigenetics & Nuclear Function |
Quality【质量】 | Evaluated by western blot on HeLa cell lysate. Western Blot Analysis: A 1:1000-1:3000 dilution of this antibody was used to detect LAP2 in HeLa cell lysate. |
Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, (pH 7.4), 150 mM NaCl, with 0.05% sodium azide. Affinity purified |
Analysis Note【分析说明】 | Control HeLa cell lysate |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human, mouse, rat, canine |
technique(s) | immunocytochemistry: suitable immunofluorescence: suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NM_003276 |
UniProt accession no.【UniProt登记号】 | P42167 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~55 kDa |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8ºC from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |