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Anti-Cyclin A Antibody

产品编号:4088196
规格:Upstate®, from rabbit
包装规格:200 μg
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088196200 μg5520
基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.
Specificity【特异性】
p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3
Immunogen【免疫原】
peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)
Application【应用】
Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function
Quality【质量】
routinely evaluated by immunoblot on HeLa nuclear extract
Physical form【外形】
Protein G Chromatography
Lyophilized
Format: Purified
Analysis Note【分析说明】
Control
Daudi cells
Legal Information【法律信息】
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
human, sheep, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NM_001237
UniProt accession no.【UniProt登记号】
P20248
shipped in【运输】
dry ice
Gene Information
human ... CCNA2(890)
产品说明
Target description【目标描述】
58kDa
Storage and Stability【储存及稳定性】
2 years at -20°C
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302 + H312 + H332 - H412
Precautionary Statements
P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
Hazard Classifications【危险分类】
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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