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Anti-SynGAP Antibody

产品编号:4088134
规格:Upstate®, from rabbit
包装规格:100 μg
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088134100 μg5520
基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.
Specificity【特异性】
SynGAP
Immunogen【免疫原】
peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a
Application【应用】
Research Sub Category
Synapse & Synaptic Biology
Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Research Category
Neuroscience
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Linkage【联系】
Replaces: 04-1071
Physical form【外形】
Format: Purified
Protein A purified
Purified in PBS with 0.05% NaN3 and 30% Glycerol
Legal Information【法律信息】
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
rat
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NM_006772.1
UniProt accession no.【UniProt登记号】
Q96PV0
shipped in【运输】
dry ice
Gene Information
human ... SYNGAP1(8831)
产品说明
Storage and Stability【储存及稳定性】
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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