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Anti-STAT1 Antibody, CT
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions. |
Specificity【特异性】 | Recognizes STAT1. |
Immunogen【免疫原】 | GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α |
Application【应用】 | Detect STAT1 also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1 Antibody, CT (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA, IP & WB. |
Quality【质量】 | routinely evaluated by immunoblot on RIPA lysates from human Jurkat cells, mouse CTLL or rat L6 cells |
Physical form【外形】 | Protein A purified Format: Purified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | purified antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
species reactivity | human, mouse |
manufacturer/tradename | Upstate® |
technique(s) | electrophoretic mobility shift assay: suitable immunoprecipitation (IP): suitable western blot: suitable |
isotype【同位素/亚型】 | IgG |
NCBI accession no.【NCBI登记号】 | NM_007315 |
UniProt accession no.【UniProt登记号】 | P42224 |
shipped in【运输】 | wet ice |
Gene Information | human ... STAT1(6772) |
产品说明
Target description【目标描述】 | 91 kDa |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |