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Anti-Interleukin 23 alpha (IL-23A) Antibody
产品编号: | 4088105 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μg |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-Interleukin 23 alpha (IL-23A) Antibody
IL-23 subunit alpha, Interleukin-23 subunit p19, JKA3 induced upon T-cell activation, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Interleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. |
Specificity【特异性】 | Antibody recognizes the mature chain of IL-23 subunit alpha. |
Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha. Epitope: Mature chain of IL-23, subunit alpha. |
Application【应用】 | Flow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC′s. Detect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC. |
Quality【质量】 | Evaluated by Western Blot in 3T3/A31 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate. |
Other Notes【其他说明】 | Affinity purified |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human, mouse |
species reactivity (predicted by homology) | rhesus monkey (based on 100% sequence homology) |
technique(s) | flow cytometry: suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_057668 |
UniProt accession no.【UniProt登记号】 | Q9NPF7 |
shipped in【运输】 | wet ice |
Gene Information | human ... IL23A(51561) |
产品说明
Target description【目标描述】 | UniProtKB/Swiss-Prot entry Q9NPF7 lists a molecular weight of 20.730 kDa In some lysates tested, non-specific bands are observed at around 40 kDa and around 55 kDa |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |