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Anti-Interleukin 23 alpha (IL-23A) Antibody

产品编号:4088105
规格:from rabbit, purified by affinity chromatography
包装规格:100 μg
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088105100 μg4840
产品别名

Anti-Interleukin 23 alpha (IL-23A) Antibody

IL-23 subunit alpha, Interleukin-23 subunit p19, JKA3 induced upon T-cell activation, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Interleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
Specificity【特异性】
Antibody recognizes the mature chain of IL-23 subunit alpha.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha.
Epitope: Mature chain of IL-23, subunit alpha.
Application【应用】
Flow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC′s.
Detect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC.
Quality【质量】
Evaluated by Western Blot in 3T3/A31 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate.
Other Notes【其他说明】
Affinity purified
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human, mouse
species reactivity (predicted by homology)
rhesus monkey (based on 100% sequence homology)
technique(s)
flow cytometry: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_057668
UniProt accession no.【UniProt登记号】
Q9NPF7
shipped in【运输】
wet ice
Gene Information
human ... IL23A(51561)
产品说明
Target description【目标描述】
UniProtKB/Swiss-Prot entry Q9NPF7 lists a molecular weight of 20.730 kDa In some lysates tested, non-specific bands are observed at around 40 kDa and around 55 kDa
【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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