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Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit
| 产品编号： | 4087758 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit
Anti-KCNH2
Anti-HERG
基本信息
| MDL number | MFCD02097212 |
| NACRES | NA.41 |
| General description【一般描述】 | The K+ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K+ channels based on the number of transmembrane domains. The voltage-gated Potassium or Kv channels belong to the 6 TM K+ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. Kv11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in Kv11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. Kv11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel Kv11.1 extracellular antibodies are specific to Kv11.1. |
| Immunogen【免疫原】 | peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog. |
| Application【应用】 | Anti-Potassium channel Kv11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of Kv11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting. |
| Physical form【外形】 | Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 106 cells) immunocytochemistry: 1:25 western blot: 1:200 using HEK-KV11.1 transfected cells |
| UniProt accession no.【UniProt登记号】 | Q12809 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... KCNH2(3757) mouse ... Kcnh2(16511) rat ... Kcnh2(117018) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
