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Anti-ZIP-8 Antibody
产品编号: | 4087632 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-ZIP-8 Antibody
Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, ZIP-8, Zrt- and Irt-like protein 8
基本信息
eCl@ss | 32160702 |
General description【一般描述】 | Zinc transporter ZIP8 (UniProt Q9C0K1; also known as BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, ZIP-8, Zrt- and Irt-like protein 8) is encoded by the SLC39A8 (also known as BIGM103, ZIP8, PP3105) gene (Gene ID 64116) in human. Zinc transporters mediate the transport of zinc ions into intracellular compartments as well as the export of excess zinc out of cells. Disruption of zinc homeostasis is responsible for many chronic neurodegenerative diseases and acute neural injuries. Excessive and inadequate levels of bioavailable zinc are detrimental to the health of neurons. Two classes of multipass transmembrane Zn transporters are known, including 10 ZnTs and 14 ZIPs, that exhibit opposing functions in mediating zinc homeostasis. These transporters are located on plasma and vesicular membranes with tissue-specific expression pattern. ZIP8 is a negative regulator of the NF-κB signaling pathway through zinc-mediated suppression of IKK activity in monocytes, macrophages, and lung epithelia. ZIP8 expression is induced following innate immune activation and correlates with intracellular zinc sequestration. Human ZIP8 is an 8-transmembrane protein (a.a. 9-29, 133-153, 161-181, 192-212, 303-323, 366-386, 389-409, 430-450) that has both its N- and C-termini (a.a. 1-8 & 451-460) exposed extracelluarly with 4 intracellular and 3 extracellular loops in between. |
Specificity【特异性】 | Immunogen sequence is present in all three spliced isoforms of human ZIP-8 reported by UniProt (Q9C0K1). |
Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to a sequence within the second extracellular loop of human ZIP-8. |
Application【应用】 | This Anti-ZIP-8 Antibody is validated for use in Western Blotting for the detection of ZIP-8. |
Quality【质量】 | Evaluated by Western Blotting in human lung tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected ZIP-8 in 10 µg of human lung tissue lysate. |
Other Notes【其他说明】 | Affinity Purified |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human |
species reactivity (predicted by homology) | nonhuman primates (based on 100% sequence homology) |
technique(s) | western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_071437 |
UniProt accession no.【UniProt登记号】 | Q9C0K1 |
Gene Information | human ... SLC39A8(64116) |
产品说明
Target description【目标描述】 | ~52 kDa observed. Target band size appears larger than the calculated molecular weights of 49.63/43.13/48.09 kDa (human isoform 1/2/3) due to glycosylation. |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |