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抗 结蛋白抗体,小鼠单克隆
Anti-Desmin antibody, Mouse monoclonal
产品编号: | 4087590 |
规格: | clone DE-U-10, purified from hybridoma cell culture |
包装规格: | 100 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
抗 结蛋白抗体,小鼠单克隆
Anti-Desmin antibody, Mouse monoclonal
Anti-DES
基本信息
NACRES | NA.41 |
General description【一般描述】 | Anti-Desmin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma DE-U-10 produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/C mouse. Desmin, a major intermediate filament protein in skeletal, cardiac and smooth muscle cells. It is predominantly localised to filamentous extrasarcomeric cytoskeleton, which links neighbouring myofibrils and connects the myofibrillar apparatus with the subsarcolemmal cytoskeleton, myonuclei and mitochondria. |
Immunogen【免疫原】 | Desmin purified from pig stomach |
Application【应用】 | Anti-Desmin antibody, Mouse monoclonal has been used in:
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Biochem/physiol Actions【生化/生理作用】 | Mutations is the desmin gene (known as desminopathy or DRM) are associated with several human diseases such as atrophy and facial muscle weakness, cardiomyopathy, cardiac arrhythmias and restrictive heart failure and are characterized by intracellular desmin aggregates. Anti-Desmin antibodies can be implemented for cancer research and diagnostics since elevated levels of desmin characterize several types of muscle tissue tumors, such as leiomyomas and rhabdomyosarcomas. The antibody may also be used for meat research measurements. |
Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
Quality Level【质量水平】 | 200 |
antibody form【抗体形式】 | purified from hybridoma cell culture |
antibody product type | primary antibodies |
clone【克隆】 | DE-U-10, monoclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~55 kDa |
species reactivity | toad, porcine, hamster, mouse, rat, goat, human, rabbit, sheep, chicken, bovine |
concentration【浓度】 | ~1.0 mg/mL |
technique(s) | immunoblotting: 0.5-1 μg/mL using whole extract of mouse myoblast C2C12 cells immunofluorescence: 2-5 μg/mL using mouse myoblast C2C12 cells immunohistochemistry: 2.5-5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Appendix microarray: suitable |
isotype【同位素/亚型】 | IgG1 |
UniProt accession no.【UniProt登记号】 | P02540 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |