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Anti-GABPA Antibody

产品编号:4087575
规格:from rabbit
包装规格:200 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4087575200 μG5350
产品别名

Anti-GABPA Antibody

GA-binding protein alpha chain, GABP subunit alpha, GABPA

基本信息
eCl@ss
32160702
General description【一般描述】
GA-binding protein alpha chain (UniProt Q00422; also known as GA repeat binding protein alpha, GABP subunit alpha, GABPalpha, NRF-2, Nuclear respiratory factor-2) is encoded by the Gabpa gene (also known as E4tf1a) in murine species (Gene ID 14390). GABPalpha is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. GABPalpha is upregulated in response to oxidant exposure or increased cellular reactive oxygen species (ROS), where it mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to mouse GABPA near the C-terminus.
Epitope: Near C-terminus
Application【应用】
Research Sub Category
Nuclear Receptors
Western Blotting Analysis: A representative lot detected GABPA in mouse liver nuclear proteins (Cherry, A.D., et al. (2014). J. Biol. Chem. 289(1):41-52).
Chromatin Immunoprecipitation Analysis: A representative lot detected GABPA occupancy at the Sod2 promoter region by ChIP using liver chromatin preparation from mice after S. aureus inoculation (Cherry, A.D., et al. (2014). J. Biol. Chem. 289(1):41-52).
Detect GABPA using this Anti-GABPA Antibody validated for use in Western Blotting and Chromatin Immunoprecipitation (ChIP).
Research Category
Epigenetics & Nuclear Function
Quality【质量】
Evaluated by Western Blotting in mouse liver tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected GABPA in 10 µg of mouse liver tissue lysate.
Physical form【外形】
Format: Purified
Protein A purified
Purified rabbit polyclonal antibody in buffer containing PBS and 0.01% Sodium Azide.
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
human, mouse, rat
species reactivity (predicted by homology)
canine (based on 100% sequence homology), monkey (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)
ChIP: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_032091
UniProt accession no.【UniProt登记号】
Q00422
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~55 kDa observed
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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