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Anti-LRRC4 Antibody

产品编号:4087478
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4087478100 μG5520
产品别名

Anti-LRRC4 Antibody

Leucine-rich repeat-containing protein 4, Brain tumor-associated protein BAG, Nasopharyngeal carcinoma-associated gene 14 protein, Netrin-G2 ligand, NGL-2

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Leucine-rich repeat-containing protein 4, or LRRC4, also known as Nasopharyngeal carcinoma-associated gene 14 protein or Netrin-G2 ligand (NGL-2), and encoded by the gene LRRC4/BAG, is a synaptic adhesion protein that regulates the formation of excitatory synapses through the recruitment of key pre and post synaptic proteins. LRRC4 is particularly important in auditory synaptic responses and LRRC4 is a key regulator of input-specific synapse development in the hippocampus as well. Finally, LRRC4 appears important in the suppression of glioma cancers in the brain and is specifically down regulated in tumors, and is currently being investigated as a potential anti-cancer target. LRRC4 is localized to the cell junctions and synapses. It is a cell membrane bound, post-synaptic, protein, and LRRC4’s expression is brain specific.
Immunogen【免疫原】
Epitope: Extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human LRRC4.
Application【应用】
Anti-LRRC4 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine-rich repeat-containing protein 4 & has been tested in western blotting & IHC.
Research Sub Category
Synapse & Synaptic Biology
Research Category
Neuroscience
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Lrrc4 in rat hippocampus tissue, whereas a 1:500 dilution from a representative lot detected LRRC4 in human cerebellum and thalamus tissues.
Quality【质量】
Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting: 1 µg/mL of this antibody detected LRRC4 in 10 µg of human brain tissue lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
rat, mouse, human
species reactivity (predicted by homology)
canine (based on 100% sequence homology), feline (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_071426
UniProt accession no.【UniProt登记号】
Q9HBW1
shipped in【运输】
wet ice
Gene Information
human ... LRRC4(64101)
产品说明
Target description【目标描述】
~100 kDa observed. This protein may be observed at higher molecular weights due to glycosylation.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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