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Anti-IL-21 Antibody
产品编号: | 4087476 |
规格: | from rabbit, purified by affinity chromatography |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-IL-21 Antibody
Interleukin-21, IL-21, Za11
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Interleukin-21 (UniProt Q9HBE4; also known as IL-21, Za11) is encoded by the IL21 (also known as CVID11) gene (Gene ID 59067) in human. IL-21 is a type I four-alpha-helical bundle cytokine primarily produced by CD4+ T cells and NKT cells. The heterodimeric receptor IL-21R is dominantly expressed by B cells and shares the common cytokine receptor gamma chain (γc) with receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Studies indicate that IL-21 potently regulates both adaptive and innate immune responses and possesses widely pleiotropic functions. IL-21 has also been linked to autoimmune disorders, allergies, inflammatory diseases, as well as the pathogenesis of cancer. Human IL-21 is initially translated with an N-terminal 22 aa signal peptide sequence, which is later removed to produce the 133 aa mature IL-21. |
Specificity【特异性】 | Expected to react with pro- and mature IL-21 of both isoform 1 and isoform 2 (IL-21iso). |
Immunogen【免疫原】 | Epitope: Near C-terminus KLH-conjugated linear peptide corresponding to human IL-21 sequence near the C-terminus. |
Application【应用】 | Research Sub Category Immunoglobulins & Immunology Flow Cytometry Analysis: 3.0 µg of this antibody detected IL-21 in human peripheral blood mononuclear cells. Research Category Inflammation & Immunology This rabbit Polyclonal Anti-IL-21 Antibody, Cat. No. ABF184 is validated for use in Western Blotting, Flow Cytometry, for the detection of IL-21. |
Quality【质量】 | Evaluated by Western Blotting in human IL-21 transfected HEK293 cell lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected IL-21 in 10 µg of human IL-21 transfected HEK293 cell lysate. |
Physical form【外形】 | Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
purified by【纯化方式】 | affinity chromatography |
species reactivity | human |
species reactivity (predicted by homology) | bovine (based on 100% sequence homology), porcine (based on 100% sequence homology) |
technique(s) | flow cytometry: suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_068575 |
UniProt accession no.【UniProt登记号】 | Q9HBE4 |
shipped in【运输】 | wet ice |
Gene Information | human ... IL21(59067) |
产品说明
Target description【目标描述】 | ~17 kDa observed. Uncharacterized band(s) may appear in some lysates. |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |