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Anti-ZC3H12A Antibody
| 产品编号： | 4087456 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ZC3H12A Antibody
Ribonuclease ZC3H12A, MCP-induced protein 1, Zinc finger CCCH domain-containing protein 12A
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Ribonuclease ZC3H12A, also known as MCP-induced protein 1 or Zinc finger CCCH domain-containing protein 12A, and encoded by the gene name ZC3H12A or MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation. ZC3H12A may be involved in host immunity and inflammatory diseases. It has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPγ. |
| Immunogen【免疫原】 | KLH-conjugated synthetic peptide corresponding to the center region of human ZC3H12A. Epitope: center region |
| Application【应用】 | Research Sub Category Immunoglobulins & Immunology Anti-ZC3H12A Antibody detects level of ZC3H12A & has been published & validated for use in ZC3H12A. Research Category Inflammation & Immunology |
| Quality【质量】 | Evaluated by Western Blotting in Raji Cell lysate. Western Blotting Analysis: 2 μg/mL of this antibody detected ZC3H12A in Raji Cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q5D1E8 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... ZC3H12A(80149) |
产品说明
| Target description【目标描述】 | ~75 kDa observed. Uncharacterized bands may be observed in some lysate(s). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
