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Anti-BRDT Antibody

产品编号:4087437
规格:from rabbit, purified by affinity chromatography
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4087437200 μL5350
产品别名

Anti-BRDT Antibody

Bromodomain testis-specific protein, Bromodomain-containing female sterile homeotic-like protein, RING3-like protein

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Bromodomain testis-specific protein (BRDT), also known as Bromodomain-containing female sterile homeotic-like protein, or RING3-like protein, and encoded by the gene BRDT/ FSRG3 is a testis-specific chromatin protein that binds specifically histone H4 acetylated at ′Lys-5′ and ′Lys-8′ (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Recent studies have shown that BRDT plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. Therefore, it is involved in the late pachytene spermatocytes development. In the post-meiotic phase of spermatogenesis, BRDT binds to hyperacetylated histones and participates in their general removal from DNA. In addition, BRDT acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids, and participates in 3′-UTR truncation of specific mRNAs in post-meiotic spermatids. BRDT is required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. BRDT is testis-specific, and expressed in the germinal cells: in the early meiotic (pachytene) spermatocytes during spermiogenesis, in the round and elongating spermatids , and in the condensed late spermatids.
Immunogen【免疫原】
GST-tagged recombinant protein corresponding to mouse BRDT.
Application【应用】
This Anti-BRDT antibody is validated for use in Immunohistochemistry for the detection of BRDT.
Quality【质量】
Evaluated by Immunohistochemistry in mouse testis tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected BRDT in mouse testis tissue.
Other Notes【其他说明】
Affinity purified
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
mouse
technique(s)
immunohistochemistry: suitable
NCBI accession no.【NCBI登记号】
NP_473395
UniProt accession no.【UniProt登记号】
Q91Y44
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
107 kDa calculated
【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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