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clasto-Lactacystin β-Lactone-CAS 154226-60-5-Calbiochem
产品编号: | 4087313 |
规格: | A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. |
CAS NO: | 154226-60-5 |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4087313 | 100 μG | 4730 |
产品别名
154226-60-5
clasto-Lactacystin β-Lactone-CAS 154226-60-5-Calbiochem
Omuralide, Proteasome Inhibitor IX
基本信息
Empirical Formula【经验(实验)分子式】 | C10H15NO4 |
Molecular weight | 213.23 |
MDL number | MFCD01076526 |
General description【一般描述】 | A cell-permeable, irreversible inhibitor of the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptide hydrolysis activities of the 20S proteasome. It is believed that in vitro, the natural product, Lactacystin (Cat. No. 426100), acts as a precursor for clasto-lactacystin β-lactone, and the later is the sole species that interacts with the proteasome. Inhibits the proteasome in intact cells (IC50 approximately 1 µM). clasto-Lactacystin β-lactone shows 5-10 fold greater potency than lactacystin in vitro. A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed that in vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target 20S proteasome |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers. |
Other Notes【其他说明】 | Corey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1. Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182. Dick, L.R., et al. 1996. J. Biol. Chem.271, 7273. Fenteany, G., et al. 1995. Science268, 726. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze |
color【颜色】 | white |
solubility【溶解性】 | DMSO: 3 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 100 μg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |