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2-二环己基膦基-2′,6′-二甲氧基联苯基

SPhos
产品编号:4087297
规格:95%
CAS NO:657408-07-6
包装规格:1 G,5 G,25 G,250 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40872971 G552
40872975 G1370
408729725 G4460
4087297250 G6450
产品别名

657408-07-6

2-二环己基膦基-2′,6′-二甲氧基联苯基

SPhos

S Phos

2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C26H35O2P
Molecular weight
410.53
MDL number
MFCD05861611
General description【一般描述】
SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
Application【应用】
SPhos may be used as a ligand in the following processes:
  • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
  • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
  • Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.

Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation
用于 Suzuki-Miyaura 偶联反应的高通用配体;芳基氯、位阻二芳基、杂二芳基化合物。
Legal Information【法律信息】
使用涉及的专利号:US 6307087;EP 1097158;JP 5758844;CA 2336691
产品性质
Assay【测定】
95%
form【形式】
powder or crystals
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
mp
164-166 ℃ (lit.)
165.5 ℃
functional group【官能团】
phosphine
SMILES string
COc1cccc(OC)c1-c2ccccc2P(C3CCCCC3)C4CCCCC4
InChI
1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3
InChI key
VNFWTIYUKDMAOP-UHFFFAOYSA-N
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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