您的位置:首页 > 产品中心 > 1716-12-7, Sodium 4-Phenylbutyrate-CAS 1716-12-7-Calbiochem
Sodium 4-Phenylbutyrate-CAS 1716-12-7-Calbiochem
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4087294 | 100 MG | 1150 |
产品别名
1716-12-7
Sodium 4-Phenylbutyrate-CAS 1716-12-7-Calbiochem
SPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I, BDK Inhibitor I
基本信息
Empirical Formula【经验(实验)分子式】 | C10H11NaO2 |
Molecular weight | 186.18 |
MDL number | MFCD00800247 |
General description【一般描述】 | An antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo. A novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Increases fetal hemoglobin production in vitro and in vivo. |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Cell permeable: no Primary Target Anti-neoplastic agent |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Tso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA110, 9728. Ozcan, U., et al. 2006. Science313, 1137. Carducci, M.A., et al. 2001. Clin. Cancer Res.7, 3047. Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol.278, C259. Lea, M.A., et al. 1999. Anticancer Res.19, 1971. Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211. Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457. Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659. Collins, A.F., et al. 1995. Blood 85, 43. Lea, M.A., et al. 1995. Anticancer Res.15, 879. Figg, W.D., et al. 1994. Anticancer Drugs 5, 336. Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (by Assay) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | white to slightly yellow |
solubility【溶解性】 | water: 10 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
InChI | 1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1 |
InChI key | VPZRWNZGLKXFOE-UHFFFAOYSA-M |
packaging【包装】 | 100 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |