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芹菜素
Apigenin
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4087243 | 5 MG | 643 | |||
4087243 | 25 MG | 1810 | |||
4087243 | 100 MG | 5070 |
产品别名
520-36-5
芹菜素
Apigenin
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
4′,5,7-Trihydroxyflavone
4 ′,5,7-三羟基黄酮
5,7-二羟基-2-(4-羟基苯基)-4-苯并吡喃酮
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C15H10O5 |
Molecular weight | 270.24 |
Beilstein | 262620 |
EC number【EC 号】 | 208-292-3 |
MDL number | MFCD00006831 |
NACRES | NA.79 |
General description【一般描述】 | Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley. |
Biochem/physiol Actions【生化/生理作用】 | Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects. 一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。 |
产品性质
Quality Level【质量水平】 | 200 |
Assay【测定】 | ≥97% (TLC) |
form【形式】 | powder |
mp | >300 ℃ (lit.) |
solubility【溶解性】 | DMSO: 27 mg/mL 1 M KOH: 50 mg/mL |
storage temp.【储存温度】 | −20℃ |
SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 |
InChI | 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
Gene Information | human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835) |
packaging【包装】 | 5 mg in glass bottle 25, 100 mg in poly bottle |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |