JAK2 Inhibitor II-CAS 1837-91-8-Calbiochem

C₆H₆Br₆

557.54

MFCD00059127

A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

Cell permeable: yes
Primary Target
JAK2 autophosphorylation
Product does not compete with ATP.
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sandberg, E.M., et al. 2005. J. Med. Chem.48, 2526.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (GC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 5 mg/mL

ambient

2-8℃

1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H

QFQZKISCBJKVHI-UHFFFAOYSA-N

25 mg in Plastic ampoule
Packaged under inert gas

GHS07

Warning

H302 - H319

P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313

Acute Tox. 4 Oral - Eye Irrit. 2

11 - Combustible Solids

WGK 3