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XIE62-1004
产品别名
500899-98-9
XIE62-1004
2-[[[3,4-bis(Phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
2-(3,4-bis(Benzyloxy)benzylamino)ethanol hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H25NO3 · HCl |
| Molecular weight | 399.91 |
| Biochem/physiol Actions【生化/生理作用】 | XIE62-1004 is a synthetic sequestosome-1 (p62, SQSTM1) ZZ domain ligand that induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregation, leading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 μM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 μM, 18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectants, as well as in wild-type, but not autophagy defective Atg5-/- MEFs (GFP-HDQ103). |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OCCNCC1=CC(OCC2=CC=CC=C2)=C(C=C1)OCC3=CC=CC=C3.Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
