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TFMB-(S)-2HG
产品别名
1445703-64-9
TFMB-(S)-2HG
(S)-2-HG-TFMB
(S)-TFMB-OTC
(S)-TFMB-2-HG
(S)-TFMB-2HG
TFMB-(S)-2-HG
(2S)-Tetrahydro-5-oxo-2-furancarboxylic acid, [3-(trifluoromethyl)phenyl]methyl ester
Trifluoromethylbenzyl-(S)-2-HG
(S)-2HG-TFMB
(S)-3-(Trifluoromethyl)benzyl 5-oxotetrahydrofuran-2-carboxylate
TFMB-L2HG
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H11F3O4 |
| Molecular weight | 288.22 |
| Biochem/physiol Actions【生化/生理作用】 | TFMB-(S)-2HG is a membrane-permeant (S)-2-hydroxyglutarate (L-2HG) precursor used in conjunction with the oncometabolite (R)-2-hydroxyglutarate (D-2HG) precursor for probing 2-HG enantiomer-specific cellular responses (typical conc used in culture: 0.5-20 mM). While both 2HG enantiomers inhibit multiple α-ketoglutarate (α-KG; 2-OG)-dependent dioxygenases by competing against α-KG binding, (S)-2HG is reported to be more potent against TET1/2, CeKDM7A & KDM5B (JARID1B/PLU-1). On the other hand, (R)-2HG, but not (S)-2HG, is shown to downregulate HIF-1a by promoting EglN1 (HIF prolyl hydroxylase 2; HIF-PH2; PHD2) activity. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
