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ETaKG
产品别名
ETaKG
5-Ethyl 1-(3-(trifluoromethyl)benzyl) 2-oxopentanedioate
2-Oxo-pentanedioic acid 5-ethyl ester 1-(3-trifluoromethyl-benzyl) ester
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H15F3O5 |
| Molecular weight | 332.27 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826049 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | ETaKG is a cell-permeable, aqueous stable, bioavailable, non-toxic α-ketoglutarate/2-oxoglutarate (α-KG/2-OG) diester derivative that readily undergoes hydrolysis by cytosolic esterases to α-KG. The monoester analog, TaKG is also membrane permeant. ETaKG elevates intracellular [α-KG] by ~15-fold in a prologned fashion, destabilizes HIF-1α/2α and reactivates prolyl hydroxylases (PHDs) in hypoxic HCT116, A431 and RPE cells at 2 mM. Further, shown to selectively trigger PHD-dependent cell death in hypoxic cells and decreases cellular [ATP] and glucose uptake. ETaKG has shown to reduce glucose metabolism, elevate [α-KG] levels and suppress A375 xenograft tumor growth (750 mg/kg of mice, p.o., q.d., 14 days). Also, induces mTORC1 lysosomal translocation and stimulates mTORC1 activity in the absence of glutaminolysis in U2OS cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | oil |
| color【颜色】 | colorless to light yellow |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C(CCC(OCC)=O)=O)OCC1=CC=CC(C(F)(F)F)=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
