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alpha-NETA
产品别名
115066-04-1
alpha-NETA
2-(alpha-Naphthoyl)ethyltrimethylammonium iodide
N,N,N-Trimethyl-γ-oxo-1-naphthalenepropanaminium iodide
α-NETA
N,N,N-Trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium iodide
a-NETA
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H20INO |
| Molecular weight | 369.24 |
| MDL number | MFCD00209857 |
| Biochem/physiol Actions【生化/生理作用】 | Originally identified as a substrate (ChA or choline)-noncompetitive, slowly reversible choline acetyltransferase inhibitor (human ChAT/BuChE/AChE IC50 = 88 nM/33.3 μM/48.6 μM; does not affect mAChRs, AChE, ChE, CrAT, ganglionic or skeletal muscular nAChRs), α-NETA is a fluorescent molecule (Ex 255 & 297 nm; Em 427 nm) also known for its trace amine-associated receptor 5 (TAAR5 EC50 = 150 nM) agonist and chemokine-like receptor-1 antagonist (IC50 = 375 nM; 7 nM chemerin-induced CMKLR1 β-ARR2 recruitment) potencies both in cultures and in animal disease models in vivo (3-20 mg/kg via ip. or sc. in rats & mice). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC=CC2=C1C=CC=C2)CC[N+](C)(C)C.[I-] |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
