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ADX71743
产品别名
1431641-29-0
ADX71743
6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydrobenzo[d]oxazol-4(5H)-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H19NO2 |
| Molecular weight | 269.34 |
| MDL number | MFCD30474715 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | ADX71743 is known to negatively regulate the effect of mGlu7 (metabotropic glutamate receptor subtype 7), which is associated with a number of anxiety disorders. ADX71743 is a brain-penetrant, selective and potent negative allosteric modulator of metabotropic glutamate receptor 7 (mGlu7). In one study ADX71743 exhibited an anxiolytic-like profile in rat and mouse models without causing impairment of locomotor activity. In another study it induced absence epileptic seizures and lethargy. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC1=CC(C)=CC=C1C2CC(OC(CC)=N3)=C3C(C2)=O |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
