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AC1903
产品别名
831234-13-0
AC1903
N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H17N3O |
| Molecular weight | 303.36 |
| MDL number | MFCD06609959 |
| NACRES | NA.77 |
| Application【应用】 | AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma. |
| Biochem/physiol Actions【生化/生理作用】 | AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease. Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS). |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
