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PKS21004
产品别名
2095521-90-5
PKS21004
(2S)-N1-[2-[([1,1′-biphenyl]-3-ylcarbonyl)amino]ethyl]-N4-(1,1-dimethylethyl)-2-[(1-oxo-3-phenylpropyl)amino]-butanediamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C32H38N4O4 |
| Molecular weight | 542.67 |
| Biochem/physiol Actions【生化/生理作用】 | PKS21004 is highly selective, potent and reversible inhibitor of the Plasmodium falciparum proteasome (Pf20S) β5 subunit. It is not active against mammalian c-20S and i-20S proteasome subunits. PKS21004 is effective against erythrocytic, sexual, and liver-stage parasites. Also it is active against parasites resistant to current antimalarials, and strains from patients in Africa. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(N[C@@H](CC(NC(C)(C)C)=O)C(NCCNC(C1=CC=CC(C2=CC=CC=C2)=C1)=O)=O)CCC3=CC=CC=C3 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
