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DM-NOFD
产品别名
865488-53-5
DM-NOFD
Dimethyl N-oxalyl-D-phenylalanine
N-Oxalyl-D-phenylalanine dimethyl ester
N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H15NO5 |
| Molecular weight | 265.26 |
| NACRES | NA.77 |
| General description【一般描述】 | Dimethyl N-oxalyl-D-phenylalanine (DM-NOFD) is a small FIH (factor-inhibiting) inhibitor molecule. |
| Biochem/physiol Actions【生化/生理作用】 | DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF). DM-NOFD efficiently reduces HIF1a CAD (C-terminal activating domain) hydroxylation in MCF-7 cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | oil |
| color【颜色】 | , colorless to dark yellow |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C(N[C@H](CC1=CC=CC=C1)C(OC)=O)=O)OC |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
