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DJ-V-159
产品别名
2253744-53-3
DJ-V-159
N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-1,3-Benzenedicarboxamide
N1,N3-Bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H12F6N4O2 |
| Molecular weight | 502.37 |
| MDL number | MFCD31807620 |
| Biochem/physiol Actions【生化/生理作用】 | DJ-V-159 is an agonist of GPRC6A, a family C G protein coupled receptor proposed to be master regulator of energy metabolism. GPRC6A is the receptor for osteocalcin, basic amino acids (e.g., L-Arginine), cations (e.g., calcium), and is a membrane receptor for testosterone. DJ-V-159 activated GPRC6A at 0.2 nM concentrations and stimulated GPRC6A-mediated ERK phosphorylation and cAMP accumulation in GPRC6A expressing HEK-293 cells. DJ-V-159 was found to stimulate insulin secretion from mouse β-cells and and lower serum glucose in wild-type mice. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
