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CD40-TRAF6 signaling inhibitor
产品别名
433249-94-6
CD40-TRAF6 signaling inhibitor
Compound 6877002
3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H17NO |
| Molecular weight | 251.32 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825690 |
| NACRES | NA.77 |
| Application【应用】 | CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB). |
| Biochem/physiol Actions【生化/生理作用】 | CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease. CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C |
| InChI | 1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+ |
| InChI key | WIFPLULEUNBSTE-GZTJUZNOSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
