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ABC1183
产品别名
1042735-18-1
ABC1183
4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile
4-[[4-Amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]-benzonitrile
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H14N4OS |
| Molecular weight | 334.39 |
| Biochem/physiol Actions【生化/生理作用】 | ABC1183 is an orally active, potent and selective inhibitor of GSK3 α/β and CDK9, which induces G2/M cell cycle arrest and apoptosis in cancer cells. Apparently ABC1183 suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms due to down regulation of TNFα and IL-6 pro-inflammatory cytokines. It does not exhibit organ or hematological toxicities. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | NC1=C(C(C2=CC=C(C=C2)C#N)=O)SC(NC3=CC=C(C)C=C3)=N1 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
