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7ACC2
产品别名
1472624-85-3
7ACC2
7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
7-Aminocarboxycoumarin 2
7-ACC2
7-[Methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
7-(N-Benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H15NO4 |
| Molecular weight | 309.32 |
| MDL number | MFCD28167835 |
| Biochem/physiol Actions【生化/生理作用】 | 7ACC2 is a monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that affects lactate uptake-dependent cancer growth in cultures (uptake/proliferation IC50 = 59/220 nM; MCT1/4-expressing SiHA cervix cancer in the absence of glucose) and in vivo (3 mg/kg/day i.p.; SiHa, HCT116, MCF-7 in mice), without affecting lactate efflux or the survival of highly glycolytic HL-60 (MCT1) or MDA-MB231 (MCT4) cancer cells. Unlike the MCT1/2 inhibitor AR-C155858, 7ACC2 does not block MCT1-mediated uptake of the anti-cancer drug 3-bromopyruvate (3-BP). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(O)C1=CC2=C(C=C(C=C2)N(C)CC3=CC=CC=C3)OC1=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
