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ET-18-OCH3-CAS 70641-51-9-Calbiochem
| 产品编号： | 4085410 |
| 规格： | A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. |
| CAS NO： | 70641-51-9 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4085410 | 5 MG | 1940 |
产品别名
70641-51-9
ET-18-OCH3-CAS 70641-51-9-Calbiochem
Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
Edelfosine, 1-O-Octadecyl-2-O-methyl- rac-glycero-3-phosphorylcholine
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H58NO6P |
| Molecular weight | 523.73 |
| MDL number | MFCD00135190 |
| General description【一般描述】 | A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties. A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Target IC50: 9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC) Reversible: yes Primary Target PI-PLC |
| Caution【注意】 | Material may form micelles in aqueous stock solutions, which may affect experimental results. |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Reconstitution【重悬】 | Following reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use. |
| Other Notes【其他说明】 | Harguindey, J., et al. 2000. Apoptosis5, 87. Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813. Powis, G., and Phil, D. 1994. Cancer Metastasis Rev.13, 91. Helfman, D., et al. 1993. Cancer Res. 53, 2955. Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603. Powis, G., et al. 1992. Cancer Res.52, 2835. Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun.157, 1000. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (TLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 5 mg/mL ethanol: 5 mg/mL chloroform: 50 mg/mL water: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3 |
| InChI key | MHFRGQHAERHWKZ-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
