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Anti-Meis 1/2/3 Antibody, clone 9.2.7
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Meis1, 2, and 3 are members of the TALE (three amino acid loop extension) family of homeodomain containing proteins. Meis1 binds to Hox and Pbx proteins to form complexes with distinct DNA-binding specificities. Like Hox and Pbx proteins, the overexpression of Meis1 in BHX-2 myeloid leukemias implies a role for this protein in oncogenesis. Two Meis related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and express in normal tissues as well as myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation. |
| Specificity【特异性】 | Meis1, Meis2, Meis3 and splice variants |
| Immunogen【免疫原】 | MBP-conjugated fusion protein corresponding to amino acids 60-390 of mouse Meis1 |
| Application【应用】 | Research Sub Category Transcription Factors Research Category Epigenetics & Nuclear Function Detect Meis 1/2/3 with Anti-Meis 1/2/3 Antibody, clone 9.2.7 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB & IHC. |
| Quality【质量】 | routinely evaluated by immunoblot on nuclear extract from K562 cells |
| Linkage【联系】 | Replaces: MABN1071 |
| Physical form【外形】 | Ascites mouse ascites IgG1 containing 0.05% sodium azide before the addition of glycerol to 30% |
| Analysis Note【分析说明】 | Control K562 nuclear extract |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | ascites fluid |
| antibody product type | primary antibodies |
| clone【克隆】 | 9.2.7, monoclonal |
| species reactivity | human, mouse |
| manufacturer/tradename | Upstate® |
| technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NM_170677 |
| UniProt accession no.【UniProt登记号】 | O14770 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... MEIS2(4212) |
产品说明
| Target description【目标描述】 | Mr ~45-66kDa |
| Storage and Stability【储存及稳定性】 | 2 years at -20°C |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
