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RAR, α human

产品编号:4084922
规格:recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
包装规格:5 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40849225 μG7220
产品别名

RAR, α human

RAR

NR1B1

基本信息
NACRES
NA.26
Biochem/physiol Actions【生化/生理作用】
Several members of the nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-α (ERα) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukemia. Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consists of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The retinoic acid receptor alpha gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). RARα is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA.
Physical form【外形】
Clear and colorless frozen liquid solution
Preparation Note【制备说明】
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in insect cells
Assay【测定】
≥70% (SDS-PAGE)
form【形式】
frozen liquid
mol wt【分子量】
~52.4 kDa
packaging【包装】
pkg of 5 μg
storage condition【储存条件】
avoid repeated freeze/thaw cycles
concentration【浓度】
1000 μg/mL
color【颜色】
clear colorless
NCBI accession no.【NCBI登记号】
NM_000964
UniProt accession no.【UniProt登记号】
P10276
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... RARA(5914)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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