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Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1
产品别名
Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1
Indoleamine 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine-pyrrole 2,3 dioxygenase, IDO1
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy. |
Specificity【特异性】 | Recognizes IDO (Indoleamine 2,3- Dioxygenase), Mr 42 kDa. |
Immunogen【免疫原】 | GST fusion protein corresponding to residues 78-184 of human Indoleamine 2,3- Dioxygenase (IDO). Clone 10.1. |
Application【应用】 | Anti-IDO (Indoleamine 2, 3-Dioxygenase) Antibody, clone 10.1 is an antibody against IDO (Indoleamine 2 for use in IC & WB. Immunocytochemistry: A previous lot was used by an independent laboratory in Phoenix cells transfected with an expression vector. Immunohistochemistry: A previous lot of this antibody was used to detect IDO in human retina, primary eye tumor and metastatic liver tumor tissue sections (Chen, P.W., et al. Experimental Eye Research 85(2007) 617-625). |
Quality【质量】 | Routinely evaluated by Western Blot on untreated and IFNgamma treated (24 hrs) Hela lysates. Western Blot Analysis: 1:500 dilution of this lot detected IDO on 10 ug of untreated and IFN gamma treated Hela lysates. |
Linkage【联系】 | Replaces: 04-1056 |
Physical form【外形】 | Format: Purified Purified mouse monoclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol. Protein G Purified |
Analysis Note【分析说明】 | Control Human IFN-gamma stimulated HeLa cell lysates, IFN gamma stimulated human peripheral blood lymphocytes. |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 10.1, monoclonal |
species reactivity | human, mouse |
manufacturer/tradename | Upstate® |
technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable (paraffin) western blot: suitable |
isotype【同位素/亚型】 | IgG |
NCBI accession no.【NCBI登记号】 | NP_002155 |
UniProt accession no.【UniProt登记号】 | P14902 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | 42 kDa |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |