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Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2
产品别名
Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2
adenosine A2 receptor, adenosine A2a receptor, adenosine receptor subtype A2a
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | Adenosine receptors, a class of purinergic G-protein coupled receptors with adenosine as endogenous ligands mediate several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The activity of A2A adenosine receptor is mediated by G proteins which activate adenylyl cyclase. It is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB and may suggest a new strategy for using this mechanism in neurodegenerative diseases. |
Specificity【特异性】 | This antibody recognizes adenosine receptor A2A, Mr 43 kDa. Cross-reactivity with guinea pig also reported. |
Immunogen【免疫原】 | 6His-tagged full-length human recombinant A2A receptor. Epitope mapped to SQPLPGER in the third intracellular loop. Clone 7F6-G5-A2. |
Application【应用】 | Research Category Neuroscience Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2 is an antibody against Adenosine Receptor A2a clone 7F6-G5-A2 for use in FC, IH & WB. Immunohistochemistry: 1 μg/mL of a previous lot detected Adenosine Receptor A2A in paraformaldehyde-fixed mouse brain striatal sections. Not detected in Adenosine Receptor A2A knockout mice. FACS Analysis: A previous lot of this antibody has been reported by an independent laboratory to detect Adenosine Receptor A2A in transfected HEK293 cells (Koshiba, M., 1999). Research Sub Category Neurofilament & Neuron Metabolism Neuronal & Glial Markers Neurodegenerative Diseases |
Quality【质量】 | Routinely evaluated by immunohistochemistry. Western Blot Analysis: A 1:1000–1:5000 dilution of this lot of antibody detected Adenosine Receptor A2A in HEK293 cells expressing canine A1/A2A receptor chimeras (Rosin, D.L., 1998). |
Physical form【外形】 | Purified mouse monoclonal IgG2ak in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide Format: Purified Protein G Purified |
Analysis Note【分析说明】 | Control Brain tissue |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 7F6-G5-A2, monoclonal |
species reactivity | rabbit, canine, human, mouse, rat, dog |
manufacturer/tradename | Upstate® |
technique(s) | flow cytometry: suitable immunohistochemistry: suitable western blot: suitable |
isotype【同位素/亚型】 | IgG2a |
NCBI accession no.【NCBI登记号】 | NM_000675 |
UniProt accession no.【UniProt登记号】 | P29274 |
shipped in【运输】 | wet ice |
产品说明
Target description【目标描述】 | ~43 kDa |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |