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Sodium Salicylate-CAS 54-21-7-Calbiochem

产品编号:4084150
规格:A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.
CAS NO:54-21-7
包装规格:5 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40841505 G889
产品别名

54-21-7

Sodium Salicylate-CAS 54-21-7-Calbiochem

Salicylic Acid, Na, NaSal

基本信息
Empirical Formula【经验(实验)分子式】
C7H5O3 · Na
Molecular weight
160.10
MDL number
MFCD00002440
General description【一般描述】
A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
Product does not compete with ATP.
Reversible: no
Warning【警告】
Toxicity: Harmful (C)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes【其他说明】
Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (titration)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
color【颜色】
off-white
solubility【溶解性】
water: 50 mg/mL
ethanol: soluble
shipped in【运输】
ambient
storage temp.【储存温度】
10-30℃
InChI
1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
packaging【包装】
5 g in Glass bottle
Packaged under inert gas
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Warning
Hazard Statements
H302 - H319 - H361d
Precautionary Statements
P201 - P202 - P264 - P301 + P312 - P305 + P351 + P338 - P308 + P313
Hazard Classifications【危险分类】
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)【闪点(F)】
208.9 °F - Pensky-Martens closed cup
Flash Point(C)【闪点(C)】
98.3 ℃ - Pensky-Martens closed cup
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