广州伟伯科技有限公司
您的位置:首页 > 产品中心 > 1188890-32-5, PI 3-Kα Inhibitor IV-CAS 1188890-32-5-Calbiochem
产品搜索:

PI 3-Kα Inhibitor IV-CAS 1188890-32-5-Calbiochem

产品编号:4084131
规格:The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
CAS NO:1188890-32-5
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40841315 MG4330
产品别名

1188890-32-5

PI 3-Kα Inhibitor IV-CAS 1188890-32-5-Calbiochem

3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV

基本信息
Empirical Formula【经验(实验)分子式】
C16H15N3O2S · 2HCl
Molecular weight
386.30
General description【一般描述】
A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-Ks (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥ 3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50<3 µM) in A375 melanoma cells.
A cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50<3 µM) in A375 melanoma cells.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Primary Target
PI 3-Kα
Target IC50: 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively
Product does not compete with ATP.
Reversible: no
Warning【警告】
Toxicity: Irritant (B)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes【其他说明】
Hayakawa, M., et al. 2006. Bioorg. Med. Chem.14, 6847.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
protect from light
color【颜色】
off-white
solubility【溶解性】
DMSO: 10 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
packaging【包装】
5 mg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0085