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PDE4D Inhibitor, GEBR-7b-Calbiochem

产品编号:4084125
规格:The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40841255 MG2380
产品别名

PDE4D Inhibitor, GEBR-7b-Calbiochem

GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C21H30N2O5
Molecular weight
390.47
MDL number
MFCD28053503
General description【一般描述】
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
Warning【警告】
Toxicity: Standard Handling (A)
Other Notes【其他说明】
Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
semisolid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
protect from light
color【颜色】
pale yellow
solubility【溶解性】
DMSO: 100 mg/mL, clear, colorless
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
SMILES string
COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1
packaging【包装】
5 mg in Glass bottle
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
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