您的位置:首页 > 产品中心 > 123653-11-2, NS-398-CAS 123653-11-2-Calbiochem
NS-398-CAS 123653-11-2-Calbiochem
产品编号: | 4084121 |
规格: | A cell-permeable selective inhibitor of COX-2 in vitro. |
CAS NO: | 123653-11-2 |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4084121 | 5 MG | 3010 |
产品别名
123653-11-2
NS-398-CAS 123653-11-2-Calbiochem
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
基本信息
Empirical Formula【经验(实验)分子式】 | C13H18N2O5S |
Molecular weight | 314.36 |
MDL number | MFCD00882995 |
General description【一般描述】 | A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes. A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 3.8 µM against COX-2 Product does not compete with ATP. Reversible: no Primary Target COX-2 |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C. |
Other Notes【其他说明】 | Ouellet, M., and Percival, M.D. 1995. Biochem. J.306, 247. Futaki, N., et al. 1994. Prostaglandins47, 55. Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259. Futaki, N., et al. 1993. Gen. Pharmacol.24, 105. Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (TLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze |
color【颜色】 | pale yellow |
solubility【溶解性】 | DMSO: 20 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 10-30℃ |
InChI | 1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3 |
InChI key | KTDZCOWXCWUPEO-UHFFFAOYSA-N |
packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |