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NS-398-CAS 123653-11-2-Calbiochem

产品编号:4084121
规格:A cell-permeable selective inhibitor of COX-2 in vitro.
CAS NO:123653-11-2
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40841215 MG3010
产品别名

123653-11-2

NS-398-CAS 123653-11-2-Calbiochem

N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide

基本信息
Empirical Formula【经验(实验)分子式】
C13H18N2O5S
Molecular weight
314.36
MDL number
MFCD00882995
General description【一般描述】
A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.
A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Target IC50: 3.8 µM against COX-2
Product does not compete with ATP.
Reversible: no
Primary Target
COX-2
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes【其他说明】
Ouellet, M., and Percival, M.D. 1995. Biochem. J.306, 247.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol.24, 105.
Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (TLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
color【颜色】
pale yellow
solubility【溶解性】
DMSO: 20 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
10-30℃
InChI
1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChI key
KTDZCOWXCWUPEO-UHFFFAOYSA-N
packaging【包装】
5 mg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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