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NF-κB Activation Inhibitor III-CAS 380623-76-7-Calbiochem
产品编号: | 4084117 |
规格: | The NF-κB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. |
CAS NO: | 380623-76-7 |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
4084117 | 5 MG | 2700 |
产品别名
380623-76-7
NF-κB Activation Inhibitor III-CAS 380623-76-7-Calbiochem
3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
基本信息
Empirical Formula【经验(实验)分子式】 | C10H5ClN4O5S |
Molecular weight | 328.69 |
MDL number | MFCD00834007 |
General description【一般描述】 | A cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation. A cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target TNF-α-stimulated NF-κB activation and upregulation of MMP-9 Product does not compete with ATP. Reversible: no Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells |
Warning【警告】 | Toxicity: Irritant (B) |
Other Notes【其他说明】 | Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun.336, 716. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | amorphous solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | light yellow |
solubility【溶解性】 | DMSO: 10 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |