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Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem

产品编号:4084113
规格:The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40841135 MG3540
产品别名

Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem

MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH2, MLCK Inhibitor IV

H-RKKYKYRRK-NH2, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV

基本信息
Empirical Formula【经验(实验)分子式】
C60H105N23O11
Molecular weight
1324.62
General description【一般描述】
A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
A highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.
Biochem/physiol Actions【生化/生理作用】
Target IC50: 50 nM against MLCK
Product does not compete with ATP.
Primary Target
Mlck
Cell permeable: yes
Reversible: no
Warning【警告】
Toxicity: Standard Handling (A)
Sequence【序列】
H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
Physical form【外形】
Supplied as a trifluoroacetate salt.
Reconstitution【重悬】
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes【其他说明】
Zolotarevsky, Y., et al. 2002. Gastroenterology123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem.42, 910.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
color【颜色】
white
solubility【溶解性】
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
packaging【包装】
5 mg in Plastic ampoule
Packaged under inert gas
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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