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Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem
产品编号: | 4084113 |
规格: | The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
包装规格: | 5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem
MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH2, MLCK Inhibitor IV
H-RKKYKYRRK-NH2, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV
基本信息
Empirical Formula【经验(实验)分子式】 | C60H105N23O11 |
Molecular weight | 1324.62 |
General description【一般描述】 | A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA. A highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP. |
Biochem/physiol Actions【生化/生理作用】 | Target IC50: 50 nM against MLCK Product does not compete with ATP. Primary Target Mlck Cell permeable: yes Reversible: no |
Warning【警告】 | Toxicity: Standard Handling (A) |
Sequence【序列】 | H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂ |
Physical form【外形】 | Supplied as a trifluoroacetate salt. |
Reconstitution【重悬】 | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
Other Notes【其他说明】 | Zolotarevsky, Y., et al. 2002. Gastroenterology123, 163. Lukas, T.J., et al. 1999. J. Med. Chem.42, 910. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥97% (HPLC) |
form【形式】 | lyophilized solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | white |
solubility【溶解性】 | water: 1 mg/mL DMSO: 5 mg/mL |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |